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KMID : 0043320170400080894
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Archives of Pharmacal Research
2017 Volume.40 No. 8 p.894 ~ p.905
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DNA hypermethylation induced by Epstein-Barr virus in the development of Epstein-Barr virus-associated gastric carcinoma
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Choi Su-Jin
Shin Yu-Su
Kang Byung-Woog
Kim Jong-Gwang
Won Kyoung-Jae
Lieberman Paul M.
Cho Hyo-Sun
Kang Hyo-Jeung
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Abstract
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Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is a recently recognized disease entity defined by the presence of EBV in gastric carcinoma cells. EBV infection causes major epigenetic alterations in the EBV genome and its cellular host genome, suggesting that EBV acts as a direct epigenetic driver for EBVaGC. One of the major epigenetic events in the viral and cellular genomes to control transcription is DNA hypo- or hyper-methylation. Particularly, local and global hypermethylation have been reported in EBVaGC. It is therefore important to understand the molecular mechanisms of DNA hypermethylation during EBVaGC carcinogenesis. To understand the functional roles of DNA methylation and suggest therapeutic target candidates for EBVaGC, we reviewed recent literature reporting DNA hypermethylation in EBVaGC. We summarized the identified candidate genes that are markedly hypermethylated in EBVaGC, which can potentially be targets for chemotherapies with demethylating agents.
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KEYWORD
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DNA methylation, Epstein-Barr virus, EBV-associated gastric carcinoma
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